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Abstract. The Ross Ice Shelf, West Antarctica, experienced an extensive melt event in January 2016. We examine the representation of this event by the HIRHAM5 and MetUM high-resolution regional atmospheric models, as well as a sophisticated offline-coupled firn model forced with their outputs. The model results are compared with satellite-based estimates of melt days. The firn model estimates of the number of melt days are in good agreement with the observations over the eastern and central sectors of the ice shelf, while the HIRHAM5 and MetUM estimates based on their own surface schemes are considerably underestimated, possibly due to deficiencies in these schemes and an absence of spin-up. However, the firn model simulates sustained melting over the western sector of the ice shelf, in disagreement with the observations that show this region as being a melt-free area. This is attributed to deficiencies in the HIRHAM5 and MetUM output and particularly a likely overestimation of night-time net surface radiative flux. This occurs in response to an increase in night-time downwelling longwave flux from around 180–200 to 280 W m−2 over the course of a few days, leading to an excessive amount of energy at the surface available for melt. Satellite-based observations show that this change coincides with a transition from clear-sky to cloudy conditions, with clouds containing both liquid water and ice water. The models capture the initial clear-sky conditions but seemingly struggle to correctly represent cloud properties associated with the cloudy conditions, which we suggest is responsible for the radiative flux errors. 

Abstract Total solar eclipses (TSEs) are impressive astronomical events that have attracted people’s curiosity since ancient times. Their abrupt alterations to the radiation balance have stimulated studies on “eclipse meteorology,” most of them documenting events in the Northern Hemisphere while only one TSE (23 November 2003) has been described over Antarctica. On 4 December 2021—just a few days before the austral summer solstice—the moon blocked the sun over the austral high latitudes, with the path of totality arching from the Weddell Sea to the Amundsen Sea, thus producing a ∼2-min central TSE. In this work we present high-resolution meteorological observations from Union Glacier Camp (80°S, 83°W), the only location with a working station under totality, and South Pole station. These observations were complemented with meteorological records from 37 surface stations across Antarctica. Notably, the largest cooling (∼5°C) was observed over the East Antarctic dome, where obscurity was ∼85% while many sectors experienced insignificant temperature changes. This heterogenous cooling distribution, at odds with the seemingly homogeneous land surface of Antarctica, is partially captured by a simple radiative model. To further diagnose the effect of the eclipse on the surface meteorology, we ran multiple pairs of simulations (eclipse enabled and disabled) using the Weather Research and Forecasting (WRF) Model. The overall pattern and magnitude of the simulated cooling agree well with the observations and reveal that, in addition to the solar radiation deficit and cloud cover, low-level winds and the height of the planetary boundary layer are key determinants of the temperature changes and their spatial variability. 

Abstract. The Ross Ice Shelf, West Antarctica, experienced an extensive melt event in January 2016. We examine the representation of this event by the HIRHAM5 and MetUM high-resolution regional atmospheric models, as well as a sophisticated offline coupled firn model forced with their outputs. The model results are compared with satellite-based estimates of melt days. The firn model estimates of the number of melt days are in good agreement with the observations over the eastern and central sectors of the ice shelf, while the HIRHAM5 and MetUM estimates based on their own surface schemes are considerably underestimated, possibly due to deficiencies in these schemes and an absence of spin-up. However, the firn model simulates sustained melting over the western sector of the ice shelf, in disagreement with the observations that show this region as being melt-free. This is attributed to deficiencies in the HIRHAM5 and MetUM output, and particularly a likely overestimation of nighttime net surface radiative flux. This occurs in response to an increase in nighttime downwelling longwave flux from around 180–200 W m-2 to 280 W m-2 over the course of a few days, leading to an excessive amount of energy at the surface available for melt. Satellite-based observations show that this change coincides with a transition from clear-sky conditions to clouds containing both liquid-water and ice-water. The models capture the initial clear-sky conditions but seemingly struggle to correctly represent the ice-to-liquid mass partitioning associated with the cloudy conditions, which we suggest is responsible for the radiative flux errors. 

Abstract The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) plays a key role in tumor progression and response to therapy. The dense PDAC stroma causes hypovascularity, which leads to hypoxia. Here, we showed that hypoxia drives long-lasting epithelial–mesenchymal transition (EMT) in PDAC primarily through a positive-feedback histone methylation–MAPK signaling axis. Transformed cells preferentially underwent EMT in hypoxic tumor regions in multiple model systems. Hypoxia drove a cell autonomous EMT in PDAC cells, which, unlike EMT in response to growth factors, could last for weeks. Furthermore, hypoxia reduced histone demethylase KDM2A activity, suppressed PP2 family phosphatase expression, and activated MAPKs to post-translationally stabilize histone methyltransferase NSD2, leading to an H3K36me2-dependent EMT in which hypoxia-inducible factors played only a supporting role. Hypoxia-driven EMT could be antagonized in vivo by combinations of MAPK inhibitors. Collectively, these results suggest that hypoxia promotes durable EMT in PDAC by inducing a histone methylation–MAPK axis that can be effectively targeted with multidrug therapies, providing a potential strategy for overcoming chemoresistance. Significance:Integrated regulation of histone methylation and MAPK signaling by the low-oxygen environment of pancreatic cancer drives long-lasting EMT that promotes chemoresistance and shortens patient survival and that can be pharmacologically inhibited.See related commentary by Wirth and Schneider, p. 1739